Search results for "Ground glass hepatocyte"

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IFN? expression inhibits LHBs storage disease and ground glass hepatocyte appearance, but exacerbates inflammation and apoptosis in HBV surface prote…

2006

BACKGROUND/AIMS Interferon gamma (IFNgamma) controls hepatitis B virus replication. As systemic application may cause severe adverse effects, approaches of liver-directed IFNgamma gene therapy may represent an attractive alternative for treatment of chronic viral hepatitis B and thus needs testing in vivo in suitable animal models. METHODS We therefore crossbred Alb-1HBV transgenic mice overexpressing the large HBV surface protein (LHBs) in their livers and developing LHBs storage disease and ground glass hepatocyte appearance with SAP-IFNgamma transgenic animals previously shown to exhibit constitutive hepatic IFNgamma expression, and analyzed the resulting double-transgenic offspring. RES…

Genetically modified mouseHepatitis B virusHepatitis B Surface AntigensHepatologyGenetic enhancementTransgeneApoptosisMice TransgenicGround glass hepatocyteGenetic TherapyBiologymedicine.disease_causePeripheral blood mononuclear cellMice Inbred C57BLInterferon-gammaMiceHepatitis B ChronicLiverApoptosisImmunologyHepatocytesmedicineAnimalsInterferon gammamedicine.drugLiver International

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